After finishing fifth in the Heisman voting in 2004, Reggie Bush became USC's first tailback since 1981 to win the trophy when he did so in 2005 with the highest percentage of points ever.

He led the nation in all-purpose running in 2005 (a Pac-10 record 2,890 yards, including a league record 513 against Fresno State) and was fourth in rushing (1,740 yards). He averaged a Pac-10 record 8.7 yards per rush that season and his 19 TDs in 2005 averaged 31.6 yards each.

He had 6,617 career all-purpose yards (with 99 plays of 20-plus yards).

USC's 2006 Rose Bowl game marked the first time that a pair of Heisman winning teammates (Bush and Matt Leinart) played in the same game.